Phenylbutazone is a member of glucocorticoid family and like other drugs in this group it has a pharmacologic effect in all cells on the body. From different effects immunosuppressive (partially or completely suppressing the immune response of an individual) and anti inflammatory actions have been more evaluated and is indicated in these medical conditions. Glucocorticoid drugs inhibit the effects of lytic enzymes (relating to or causing lysis in tissues and cells as a destruction effect), which are released in inflammations and severe stress conditions. Also the phagocytosis effect by macrophages will be decreased.
Phenylbutazone is another active ingredient in this product belongs to NSAIDs group of drugs and its mechanism of action is different from dexamethasone. Like other NSAID drugs phenylbutazone inhibits the prostaglandin’s inflammatory effects that produce pain and inflammation in the body. By this mechanism other effects of prostaglandins like fever is also blocked. Besides phenylbutazone interfere in early stage of inflammation and reduce the permeability of vascular beds and prevent from edema and diapedesis (the passage of blood cells through the intact walls of the capillaries, typically accompanying inflammation).
By the combination of two active ingredients with different mechanism of action anti-inflammatory and pain relief of this product is predominant.
Indications of use
Anti inflammatory, antipyretic and analgesic. Musculoskeletal inflammations like arthritis, osteoarthritis, laminitis and tendonitis in horses.
Dosage and route of administration
Horses: 20 ml/day by slow IV injection that can be repeated depending on the severity of the conditions.
Foals: Slow IV or deep IM: 6 – 10 ml to be repeated 24 -48 hours later depending on the severity of the case.
Contraindications
In case of vascular brittle and congestion the recommended dose must be decreased and the second dose must not be applied.
Also in the animals with heart, liver or kidney problems or in the end term of pregnancy this product is contraindicated.
Withdrawal Time
None
Precautions
After the use of first dose the remaining medicine can be used in 28 days.
Protect the vials in boxes and out of the direct sun light.
Do not use concomitantly with NSAIDs and other corticosteroid drugs. IV injection must be done slowly.
Do not use more than recommended dosage.
Do not sale without veterinary prescription.
Keep out of reach of children.
Storage conditions
Protect in 15 – 25° C and direct sun light.
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