Pentosan Injection (Zycosan) – Advanced Osteoarthritis Therapy for Horses

What Is Pentosan Injection?

Pentosan polysulfate sodium (PPS), marketed as Zycosan, is the first FDA‑approved injectable treatment for osteoarthritis in horses. Osteoarthritis is a progressive joint disease that causes lameness, stiffness, and swelling, significantly impacting performance and quality of life. Pentosan Injection is a disease‑modifying osteoarthritis drug (DMOAD), meaning it not only relieves symptoms but also helps protect joint cartilage.

How Pentosan Works

The exact mechanism is not fully understood, but research shows PPS:

• Stimulates hyaluronic acid production → improves joint lubrication and shock absorption.
• Preserves proteoglycan content in cartilage → slows degeneration.
• Inhibits proteolytic enzymes → reduces cartilage breakdown.
• Improves blood flow in joint tissue → supports healing and regeneration.
• Provides mild anticoagulant effects → requires monitoring in horses with bleeding risks.

Dosage & Administration

• Route: Intramuscular injection (neck muscle).
• Dosage: 3 mg/kg (≈1.4 mg/lb) once weekly for 4 weeks (total of 4 doses).
• Packaging: Supplied in 7.5 ml single‑use vials.
• Onset: Clinical improvement often seen by Day 28, with ~60% reduction in lameness scores in field studies.

Indications

Pentosan Injection is indicated for:

• Equine osteoarthritis (OA) in performance and leisure horses.
• Horses showing lameness, stiffness, or reduced mobility.
• Long‑term management of degenerative joint disease.

Benefits of Pentosan Injection

• FDA‑approved → proven safety and efficacy.
• Disease‑modifying → not just symptom relief, but cartilage protection.
• Improves mobility → horses regain flexibility and comfort.
• Enhances performance → better stamina and reduced downtime.
• Safe alternative to long‑term NSAID use.

Safety & Precautions

• Common side effects: Injection site reactions (pain, swelling, redness), mild fever, lethargy.
• Serious risks: Prolonged clotting times (PT/aPTT) → avoid use near surgery or with anticoagulants.
• Contraindications: Horses with clotting disorders, hypersensitivity to PPS, or intended for human consumption.
• Not evaluated in: Pregnant, lactating mares, or horses under 2 years old.

Veterinarians should monitor blood chemistry and clotting parameters during treatment, especially if NSAIDs are used concurrently.

Global Availability

Prime Equine Meds ensures secure and reliable access to Pentosan Injection across multiple regions:

• UK & Ireland – Veterinary‑approved sourcing with fast delivery.
• Canada & USA – Licensed distribution with compliance to local regulations.
• Australia & New Zealand – Safe import channels for equine use.
• Europe (Germany, France, Spain, Portugal, Switzerland, etc.) – Multilingual support and EU‑compliant supply chain.

Why Choose Prime Equine Meds?

• Authenticity Guaranteed: Genuine Zycosan pentosan polysulfate sodium injections.
• Worldwide Shipping: Covering major European countries, UK, Canada, and Australia.
• Expert Support: Guidance on safe handling, dosage, and administration.
• Customer Confidence: Transparent policies, secure checkout, and responsive service.

Pentosan Injection (Zycosan) is a breakthrough therapy for equine osteoarthritis, offering both symptom relief and cartilage protection. With FDA approval and proven clinical results, it is a trusted solution for horse owners and veterinarians worldwide. Prime Equine Meds is committed to providing safe, authentic, and accessible Pentosan Injection, ensuring your horses perform at their best and enjoy improved quality of life

For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine, camels, alpacas and pigeons. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseas 

If intra-articular use is required, administer 1mL by sterile intra-articular injection.  PPS has an affinity for cartilage and active drug levels will accumulate for several days after administration.  For maximum effect, tissues should be exposed to the drug over an extended period, hence the four injections.  A period of improvement for up to six months following a course of four injections may be expected.  If at any time during this period the horse becomes sore (e.g. following a particular activity), it is safe to administer a further injection to settle any inflammatory process.
BUY PENTOSAN INJECTION is particularly effective and displays synergy with concurrent use of COSEQUIN EQUINE (Glucosamine and Chondroitin sulfate supplement) to provide the essential raw materials for joint repair and maintenance.